Medical Studies Penis Enlargement2018-08-20T14:25:23+00:00

The use of Hyaluronic Acid Injecton in Penis Enlargement

Studies have been undertaken since 2002 in order to determine the suitability of injectable Hyaluronic acid gel for penile girth enhancement.  In relation to the use of Hyaluronic acid in the face, studies go back to the 1980s and show the substance to be safe and effective.

Hyaluronic acid based filler was an effective technique to enhance penis size with no inflammatory signs or serious adverse reactions in all participants.


‘The Effects of Penile Girth Enhancement using Injectable Hyaluronic Acid Gel, a Filler’ – The Journal of Sexual Medicine (2011)

Authors : Tae Il Kwak MD, MiMi Oh MD, Je Jong Kim MD and Du Geon Moon MD

Available here


Introduction. Despite the debates on penile girth enhancement (PGE), demands for enhancement are increasing. Recently, various fillers have been widely used for soft tissue augmentation with proven efficacy and safety.

Aims. To identify the feasibility and efficacy of PGE by injection of filler.

Methods. Fifty patients with subjective small penis who visited Korea University Guro outpatient clinic were enrolled and prospectively followed. Restylane Sub-Q (Q-med, Upssala, Sweden) was injected into the fascial layer of penile body via 21G cannula with “Back & Forth Technique” and homogenized with a roller.

Main Outcome Measures. From April 2006 to February 2008, 50 patients were enrolled and 41 patients were followed until 18 months after PGE. Changes in penile girth at midshaft were measured by tapeline at 1 and 18 months. Patient’s visual estimation of residual volume (Gr 0–4), patient’s satisfaction (Gr 0–4), and any adverse reactions were also evaluated.

Results. Mean injected volume was 20.56 cc (18–22). Compared with basal girth of 7.48 ± 0.35 cm, maximal circumference was significantly increased to 11.41 ± 0.34 cm at 1 month (P < 0.0001) and maintained as 11.26 ± 0.33 cm until 18 months. In patient’s visual estimation, two patients complained the decrease as Gr 3 with focal depression at 1 month. At 18 months, all patients answered as Gr 4 without asymmetry. Patient’s and partner’s satisfaction score was 3.71 ± 0.46 and 3.65 ± 0.48 at 1 month and 3.34 ± 0.53 and 3.38 ± 0.49 at 18 months. There were no inflammatory signs or serious adverse reactions in all cases.

Conclusions. Considering the property of material, methods, and follow-up results of 18 months, PGE using filler is a very effective and safe technique for penile augmentation. 

‘Use of Macrolane VRF 30 [Hyaluronic Acid] in emicircumferential penis enlargement’ – Aesthetic Surgery Journal / The American Society for Aesthetic Plastic Surgery 33.2 (Feb 2013): 258-64

Authors : Sito, Giuseppe; Marlino, Sergio; Santorelli, Adriano

Available here


Background. Penis enlargement is increasingly in demand. Methods for penis enlargement can be classified into surgical, nonsurgical (filling), and mechanical. Each method has shown only relatively successful results. A new formulation of injectable, stabilized, hyaluronic acid (HA)-based, nonanimal gel is available that may have applications for this use.

Objectives. The authors propose a new technique for emicircumferential-injection filling of the penis and assess the safety and efficacy of this procedure compared with lipofilling [fat grafting, fat injection].

Methods. The authors retrospectively reviewed the charts of 83 patients who underwent penis enlargement with either their HA-injection technique or lipofilling between December 2007 and July 2011. Safety, efficacy, and patient satisfaction were assessed.

Results. The circumferential enlargement obtained from both techniques ranged from 3.2 to 4.5 cm, with a decrement during erection. In all patients, the increase in penis length ranged from 1.8 to 3.6 cm.

No complications were seen in patients treated with HA [Hyaluronic Acid], whereas 8 patients treated with lipofilling [fat grafting, fat injection] developed granuloma, and another experienced fat necrosis.

The vast majority (n = 72) of patients reported being “very satisfied” with the results.

Conclusions. The ideal technique for penis enlargement should be nonsurgical, with a satisfactory and predictable result, a low rate of complications, and long-term stability. Emicircumferential enlargement with HA [Hyaluronic Acid] filler meets these requirements. However, results have been durable but not definitive, and repeated treatment (with associated costs) is necessary.

‘Effects of hyaluronic acid gel in penile augmentation’  Int Journal of Impotence Research 2002; 14 (Suppl 3): S40

Authors: Moon DG, Kwak TI, Kim JJ. Cho HY.

Preliminary study 2002.

Available here


‘Injection of Hyaluronic Acid gel into the penis glans’ – International Journal of Impotence Research (2003) 15, 439–443

Moon DG, Kwak TI, Kim JJ. Cho HY

Available here


In human glans penis, injecting hyaluronic acid gel into the dermis was not so difficult and the implants showed long-term residence in the patient’s visual estimation and resulted in high satisfaction rate of patients. These results suggest that injectable hyaluronic acid gel is a safe and effective material for soft-tissue augmentation in patients with small glans penis. Long-term efficacy of more than 1 y needs to be demonstrated.

‘Glans Penis Augmentation Using Hyaluronic Acid Gel as an Injectable Filler’

World Journal of Mens Health (2015) Aug; 33(2): 50–61.

Moon DG, Kwak TI, Kim JJ

Available here


‘A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation’

– International Journal of Impotence Research   2013 May;25(3):117-20. doi: 10.1038/ijir.2013.13. Epub 2013 Apr 4.

Available here


Note : There is insufficient information to reliably predict the amount of permanent penis girth gain stimulated by neocollagenesis.

  • Neocollagenesis : New collagen formation stimulated by HA (permanent tissue gain).

‘The Lasting Effects of Fillers through Neocollagenesis’ The Dermatologist: Issue Number: Volume 22 – Issue 4 – April 2014

Authors : Cathy L. Koger, DO, and Joel L. Cohen, MD, FAAD

Available here

‘In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin’ Arch Dermatol,2007;143(2):155-163.

Authors : Wang F, Garza LA, Kang S, et al.

Available here

‘Association between collagen production and mechanical stretching in dermal extracellular matrix: in vivo effect of cross-linked hyaluronic acid filler. A randomized, placebo-controlled study’ J. Dermatol Sci. 2013;69(3):187-194.

Authors : Turlier V, Dellalleau A, Casas C, et al.

Available here

Permanent Girth Gain

Permanent increase in penis thickness stimulated by the injection of Hyaluronic acid filler has also been reported by Senior Korean Urologist Dr Kim Jin Hong.

Dr Kim Hong is a pioneer of the treatment with over 4,000 procedures performed and numerous publications in medical journals on the use of HA in penis enlargement.

“Hyaluronic acid injections increase penis size by adding volume to the penile tissues. It is naturally integrated into the tissue and will undergo isovolumic degradation in the long term, approximately 4% per month.

Note: nothing about your body is “permanent”. Every part changes over time. We define “permanent” as a result that changes very little over a very long period of time.

We define “temporary” as a procedure such as HA which will decrease in volume from 20 ml to about 12.25 ml in one year.

Older and less specialized varieties of HA continued to decrease over the second year, providing a “permanent” gain of about 39% of the original HA volume. About 61% of the gains were “temporary”.

But current varieties of HA specifically for penis enlargement is more durable and serve as a scaffold longer, resulting in creation of permanent new tissue that is about 50% of injected HA volume. It is the most effective ever and is continually being improved.

Many men consider that an acceptable cumulative and “permanent” gain. You never go back to the starting point.”











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About the author

Clinic Director Dr Gary Horn

Dr Gary Horn is the owner and director of the Androfill Clinic and is responsible for all website content.

Dr Horn is a registered Plastic Surgeon in the UK (GMC 4267803) and Belgium.

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Dr Gary Horn is a highly acclaimed Consultant Plastic and Reconstructive Surgeon and Uro-Andrologist with over 25 years of experience.

Dr Horn has published widely in international journals and is regularly invited to give lectures and to perform live surgery and non-surgical procedures.

Dr Horn has been filmed by the BBC for the Plastic Fantastic series.

In 2016 Dr Horn was filmed performing penis enlargement surgery for a BBC documentary The Penis Extension Clinic